Faculty introduction

HOSEKI Jun 寳関 淳
  • Professor
  • Department of Applied Biological Sciences, Faculty of Bioenvironmental Sciences
Faculty Profile
Research Field

Cell Biology, Molecular Biology, Biochemistry, and Protein Engineering

Academic Degrees

Doctor of Science (Ph.D., Osaka University)

Brief Biography

Dr. Jun Hoseki grew up in Nishinomiya City, Hyogo Prefecture, and completed his undergraduate and graduate studies at Kyoto University. During his university days, he was a choir member, and even now, he still enjoys singing. After graduating from Kyoto University, he worked as a researcher for a private company for a year before returning to academia and earning his Ph.D. from Osaka University. Before joining KUAS, Dr. Hoeski worked at several universities and a research institute, with a majority of that time being spent working and researching at Kyoto University.

Related Links

researchmap

Research Overview

We are analyzing the mechanisms of abnormal intracellular protein quality control caused by aging and lifestyle habits from the perspective of redox in cells.

List of Researches
Research Keywords

Cellular protein quality control, Endoplasmic reticulum, Mitochondria, Redox

Academic Papers

主要な論文
・Homeostasis of the ER redox state subsequent to proteasome inhibition.
Oku Y., Kariya M., Fujimura T., Hoseki, J., Sakai, Y.
Sci Rep. (2021) 11, 8655.
・Screening of dietary antioxidants against mitochondria-mediated oxidative stress by visualization of intracellular redox state.
Maharjan S., Sakai, Y. Hoseki, J.
Biosci. Biotech. Biochem. (2016) 80, 726-734. (日本農芸化学会 2016年 BBB 論文賞受賞)
・Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition.
Maharjan S., Oku M., Tsuda M., Hoseki, J., Sakai, Y.
Sci Rep. (2014) 4, 5896.
・Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5.
Hagiwara, M., Maegawa, K., Suzuki, M., Hoseki, J., Nagata, K., Inaba, K. et al.
Mol. Cell (2011) 41, 432-444.
・ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.
Ushioda, R., Hoseki, J., Araki, K., Jansen, G., Thomas, DY., Nagata, K.
Science (2008) 321, 569-572.
・Directed evolution of thermostable kanamycin-resistance gene: a convenient selection marker for Thermus thermophiles.
Hoseki, J., Yano, T., Koyama, Y., Kuramitsu, S., Kagamiyama, H.
J. Biochem. (1999) 126, 951-956. (日本生化学会 1999 年度 J. Biochem. 論文賞受賞)

Message

Just a single cell in the human body contains tens of thousands of different proteins working inside it. These proteins need to be properly maintained and function correctly for us to stay healthy. However, when our bodies age or when we don't live a healthy lifestyle, these proteins might not be maintained properly, which can cause various diseases. We invite you to help us understand how our cells keep these proteins lively and contribute to improving human health!

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